Human Sera
Cayman Chemical NBenzylacetamIdInhydrobro 50mg
An inhibitor of Tph1 that blocks the biosynthesis of gut-derived serotonin prevents the development of and fully rescues in a dose-dependent manner osteoporosis in ovariectomized and aged
Cayman Chemical AEBSFhydrochlorIde 50mg
An inhibitor of PKB/Akt activity (IC50 10-50 UM) that inhibits insulin-stimulated glucose transport and intracellular protein translocation inhibits additional serine/threonine kinases including PKA (IC50 20 UM) p90 S6 (IC50 50 UM) and MAP kinase (IC50 35 UM)
Cayman Chemical OlopatdInhydrochlorIde 100mg
An internal standard for the quantification of ent-8-iso-PGF2a by GC- or LC-MS
Cayman Chemical IrInotecnhydrochLRIde hyd 50mg
Source Active recombinant human N-terminal His-tagged PAD4 expressed in E coli Amino acids 2-663 (full length) MW 75 8 kDa
Cayman Chemical NItazoxnIde 50mg
mmunogen Peptde from an nternal regon of human GPX4 Host Rabbt Speces Reactvty ( ) Human mouse rat and porcne GPX4 Applcaton HC WB
Cayman Chemical RhodamIn 123chlorIde 100mg
An a2-AR agonist (Kis 61.66 69.18 and 134.9 nM for a2A- a2B- and a2C-ARs respectively) stimulates [35S]GTPYS binding to HEK293 cell membranes expressing human receptors (EC50s 26.92 56.23 and 912.01 nM for a2A- a2B- and a2C-ARs respectively) binds to I1-imidazoline sites in a variety of cell and tissue types (Kds 4-15 nM) induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine at 10 M induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings at 10 M reduces mean blood pressure and heart rate when administered via microinjection to the NRL of anesthetized normotensive cats at 0.1 and 1 g/kg
Cayman Chemical 1a 1b-dihomo Prostaglandin E2
A potent inhibitor of FTase blocking farnesylation of H-Ras N-Ras and K-Ras4B with IC50 values of 0.8 1.2 and 2.0 nM respectively displays over 50000-fold selectivity for FTase over geranylgeranyltransferase I
Cayman Chemical 25C-NB3OMehydrochlorIde 50mg
An orally bioavailable inhibitor of HIV-1 integrase (IC50 15 nM in a strand transfer assay) inhibits the spread of HIV-1IIIb infection in MT-4 cell culture (CIC95s 19 and 31 nM in medium containing 10 heat-inactivated FBS or 50 normal human serum respectively) is metabolized in the liver primarily by UGT1A1
Cayman Chemical ProcarbazInhydrochlorIde 50mg
Antibody EquipmentParts & ProcarbazInhydrochlorIde 50mg
Cayman Chemical PemIrolastpotasIum salt 100mg
A competitive inhibitor of human lysosomalBglucosidase (Ki 0.016-0.025 UM IC50 0.06 UM) that interacts with the catalytic pocket ofBglucosidase acting as a chemical chaperone that stabilizes and/or promotes the folding of the enzyme increases lysosomalBglucosidase activity by 2- to 3-fold in mutant N370S Gaucher fibroblasts
Cayman Chemical 2Chloro4nItrophenylaDgl 50mg
A B1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity often used to examine the activity of the drug-transporting MDR1 gene product P-glycoprotein
Cayman Chemical SureLIghtAlophycocynInA 50mg
Immunogen Synthetic peptide from the C-terminal region of human eNOS Host Rabbit Species Reactivity ( ) bovine and human Cross Reactivity (−) iNOS and nNOS Application WB
Cayman Chemical 2Ethyl5 7dImethyl3HImIda 100mg
A selective small molecule inhibitor of PIP5K1C (IC50 41 nM Kd 51 nM) decreases PIP2 membrane levels in cultured DRG neurons by 45 significantly reducing calcium signaling displays antinociceptive effects in mouse models of chronic pain
Cayman Chemical SIsunatovIr 50mg
A mitochondrial citrate transporter inhibitor decreases the OCR in tumor spheres isolated from patients with NSCLC and inhibits the invasion of lung cancer stem cells in vitro acts synergistically with cisplatin to reduce the viability of cisplatin-resistant patient-derived NSCLC cells at 50 UM reverses increases in body weight steatosis and fasting blood glucose levels in a mouse model of high fat-diet induced NAFLD at 50 mg/kg